Whole-genome sequencing analysis of structural variants in oesophageal adenocarcinoma

Whole genome sequencing analysis of lung adenocarcinoma in Xuanwei, China

BACKGROUND The lung cancer mortality rate in Xuanwei city is among the highest in China and adenocarcinoma is the major histological type. Lung cancer has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons; however, the pathogenesis of lung cancer has not yet been fully elucidated. METHODS We performed whole genome sequenc...

Whole-genome sequencing of nine esophageal adenocarcinoma cell lines

Esophageal adenocarcinoma (EAC) is highly mutated and molecularly heterogeneous. The number of cell lines available for study is limited and their genome has been only partially characterized. The availability of an accurate annotation of their mutational landscape is crucial for accurate experimental design and correct interpretation of genotype-phenotype findings. We performed high coverage, ...

Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants.

We compared whole-exome sequencing (WES) and whole-genome sequencing (WGS) in six unrelated individuals. In the regions targeted by WES capture (81.5% of the consensus coding genome), the mean numbers of single-nucleotide variants (SNVs) and small insertions/deletions (indels) detected per sample were 84,192 and 13,325, respectively, for WES, and 84,968 and 12,702, respectively, for WGS. For bo...

study of structural diversity of genome iranian native dog and wolf with the method whole genome sequencing

in this research, samples were collected from three iranian native dogs and three wolves. whole-genome sequencing for each individual was performed using next-generation sequencing technology. all short reads were aligned to the reference genome using bwa tool. single-nucleotide polymorphisms (snps) and small insertions and deletions (indels) were detected using the genome analysis toolkit (gat...

Whole Genome Sequencing: An Efficient Approach in Food Safety Management System